All functions

AnalysisConfiguration

Analysis Configuration

AnalysisParameters

Analysis parameters

AnalysisTableAnnotation

Create Annotation

Benchmark

Benchmark R6 class

Contrasts

Estimate contrasts using Wald Test

ContrastsInterface

Base class for all Contrasts classes

ContrastsMissing

Compute contrasts with group mean imputation

ContrastsModerated

Limma moderated contrasts

ContrastsPlotter

plot contrasts

ContrastsProDA

ContrastsProDA Wrapper to results produced by proDA

ContrastsROPECA

ROPECA reproducibility-optimization method

ContrastsTable

holds results when contrasts are added.

INTERNAL_FUNCTIONS_BY_FAMILY

Internal Functions by category

LFQData

LFQData R6 class

LFQDataAggregator

Decorates LFQData with methods to aggregate protein intensities aggregates intensities

LFQDataPlotter

LFQDataPlotter ---- Create various visualization of the LFQdata

LFQDataStats

Decorates LFQData with methods to compute statistics of interactions

LFQDataSummariser

Summarize LFQData

LFQDataToSummarizedExperiment()

converts LFQData object to SummarizedExperiment

LFQDataTransformer

Decorate LFQData with Methods for transforming Intensities

LFQDataWriter

Write LFQData, or provide outputs for writing.

LR_test()

Likelihood ratio test

MissingHelpers

compute group mean by LOD

Model

R6 class representing modelling result

ModelInterface

R6 interface class representing modelling result

PACKAGE_DATA

Package Data

build_model()

Build protein models from data

create_config_Skyline() create_config_Spectronaut_Peptide() create_config_MQ_peptide() create_config_MSFragger_MSstats()

Cenerate instances of AnalysisTableAnnotation

ionstar_bench_preprocess()

prepare benchmark data

make_benchmark()

make Benchmark

merge_contrasts_results()

Merge contrast results coming from two different model.

nr_obs_experiment()

Aggregates e.g. protein abundances from peptide abundances

nr_obs_sample()

Aggregates e.g. protein abundances from peptide abundances

old2new()

Convert old proflqua configurations (prolfqua 0.4) to new Analysis configurations prolfqua 0.5

prolfqua_data()

load data from prolfqua

sim_lfq_data()

simulate protein level data with two groups

sim_lfq_data_2Factor_config()

Simulate data, protein, with config with 2 factros Treatment and Background

sim_lfq_data_peptide_config()

Simulate data, protein and peptide, with config

sim_lfq_data_protein_config()

Simulate data, protein, with config

squeezeVarRob()

Robustly Squeeze Sample Variances

strategy_lmer() strategy_lm() strategy_rlm() strategy_glm()

Create custom lmer model

summarize_stats_factors()

compute var sd etc for all factor levels

which_missing()

add missing values to x vector based on the values of x